Despite their efforts, many morbidly obese people continue to consume too much food (hyperphagia) compared to their reserves and their needs. And yet, the hunger hormone, called ghrelin, is most frequently found at a normal or even lower level in these patients. Research can now explain this mechanism causing this paradoxical hyperphagia. Certain antibodies have a greater affinity for ghrelin in obese patients, leading to extended appetite stimulation.