Novel oncogenic RET mutation found in small cell lung cancer

For the first time, an oncogenic somatic mutation at amino acid 918 in the rearranged during transfection protein has been identified in small cell lung cancer tumors and enforced expression of this mutation within small cell lung cancer tumor cell lines produced increased intracellular signaling and cell growth.

Fuente : http://feeds.sciencedaily.com/~r/sciencedaily/~3/i...